Post by Nadica (She/Her) on Jul 14, 2024 23:04:30 GMT
Harnessing immunity: Immunomodulatory therapies in COVID-19 - Published June 25, 2024
Abstract
An overly exuberant immune response, characterized by a cytokine storm and uncontrolled inflammation, has been identified as a significant driver of severe coronavirus disease 2019 (COVID-19) cases. Consequently, deciphering the intricacies of immune dysregulation in COVID-19 is imperative to identify specific targets for intervention and modulation. With these delicate dynamics in mind, immunomodulatory therapies have emerged as a promising avenue for mitigating the challenges posed by COVID-19. Precision in manipulating immune pathways presents an opportunity to alter the host response, optimizing antiviral defenses while curbing deleterious inflammation. This review article comprehensively analyzes immunomodulatory interventions in managing COVID-19. We explore diverse approaches to mitigating the hyperactive immune response and its impact, from corticosteroids and non-steroidal drugs to targeted biologics, including anti-viral drugs, cytokine inhibitors, JAK inhibitors, convalescent plasma, monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2, cell-based therapies (i.e., CAR T, etc.). By summarizing the current evidence, we aim to provide a clear roadmap for clinicians and researchers navigating the complex landscape of immunomodulation in COVID-19 treatment.
Core Tip: Effective management of coronavirus disease 2019 (COVID-19) requires a nuanced approach that harnesses the host’s immune response Immunomodulatory therapies play a pivotal role in fine-tuning the immune system, striking a balance between defense and avoiding excessive inflammation. In line with this, increased precision in targeting specific immune pathways, alongside personalized treatment strategies, holds promise in optimizing outcomes for COVID-19 patients. This paper explores the evolving landscape of immunomodulation, emphasizing its potential as a crucial component in the therapeutic arsenal against the virus.
Keywords: Immunomodulation, COVID-19, SARS-CoV-2, Immunotherapy, Antiviral immune response, Cytokine storm, Adaptive immunity, Therapeutic strategies, Immune modulators, Viral infection, Host immune response
Abstract
An overly exuberant immune response, characterized by a cytokine storm and uncontrolled inflammation, has been identified as a significant driver of severe coronavirus disease 2019 (COVID-19) cases. Consequently, deciphering the intricacies of immune dysregulation in COVID-19 is imperative to identify specific targets for intervention and modulation. With these delicate dynamics in mind, immunomodulatory therapies have emerged as a promising avenue for mitigating the challenges posed by COVID-19. Precision in manipulating immune pathways presents an opportunity to alter the host response, optimizing antiviral defenses while curbing deleterious inflammation. This review article comprehensively analyzes immunomodulatory interventions in managing COVID-19. We explore diverse approaches to mitigating the hyperactive immune response and its impact, from corticosteroids and non-steroidal drugs to targeted biologics, including anti-viral drugs, cytokine inhibitors, JAK inhibitors, convalescent plasma, monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2, cell-based therapies (i.e., CAR T, etc.). By summarizing the current evidence, we aim to provide a clear roadmap for clinicians and researchers navigating the complex landscape of immunomodulation in COVID-19 treatment.
Core Tip: Effective management of coronavirus disease 2019 (COVID-19) requires a nuanced approach that harnesses the host’s immune response Immunomodulatory therapies play a pivotal role in fine-tuning the immune system, striking a balance between defense and avoiding excessive inflammation. In line with this, increased precision in targeting specific immune pathways, alongside personalized treatment strategies, holds promise in optimizing outcomes for COVID-19 patients. This paper explores the evolving landscape of immunomodulation, emphasizing its potential as a crucial component in the therapeutic arsenal against the virus.
Keywords: Immunomodulation, COVID-19, SARS-CoV-2, Immunotherapy, Antiviral immune response, Cytokine storm, Adaptive immunity, Therapeutic strategies, Immune modulators, Viral infection, Host immune response