Post by Nadica (She/Her) on Jul 9, 2024 3:39:43 GMT
Looking at Long Covid - Published July 4, 2024
This article summarizes a bunch of covid research
The term “Long Covid” covers a diverse array of symptoms that an individual might experience weeks to years after infection with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). Many drivers of Long Covid have been proposed, with supporting data for each. Peluso et al. now provide compelling evidence for two potential contributors: persistent SARS-CoV-2 and aberrant T cell activation. The authors used whole-body positron emission tomography (PET) imaging with a tracer that selectively tags activated T cells and showed that people with Long Covid had certain tissues that were enriched for activated T cells, and those without Long Covid did not. Moreover, because the gut was one of the sites of activated T cell enrichment, the authors analyzed gut biopsies from a subset of individuals with Long Covid. In these samples, the authors were able to identify the presence of SARS-CoV-2 RNA, and this feature was consistent across all five samples analyzed. These data suggest that viral persistence and sustained immune activation are linked to Long Covid.
This article summarizes a bunch of covid research
The term “Long Covid” covers a diverse array of symptoms that an individual might experience weeks to years after infection with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). Many drivers of Long Covid have been proposed, with supporting data for each. Peluso et al. now provide compelling evidence for two potential contributors: persistent SARS-CoV-2 and aberrant T cell activation. The authors used whole-body positron emission tomography (PET) imaging with a tracer that selectively tags activated T cells and showed that people with Long Covid had certain tissues that were enriched for activated T cells, and those without Long Covid did not. Moreover, because the gut was one of the sites of activated T cell enrichment, the authors analyzed gut biopsies from a subset of individuals with Long Covid. In these samples, the authors were able to identify the presence of SARS-CoV-2 RNA, and this feature was consistent across all five samples analyzed. These data suggest that viral persistence and sustained immune activation are linked to Long Covid.