Post by Nadica (She/Her) on Dec 4, 2024 4:24:12 GMT
Clinical Manifestation of Alopecia Areata After COVID-19 Infection or Vaccination - Published April 2, 2024
Saving despite my absolute hatred for grouping together vaccine and infection: They don't even correct for the possibility of those people getting covid before or after vaccination, it's just "oh they got alopecia after a vaccination. That's a data point." They're wrong. It's not good science. It's conflation at best and corruption at worst. Some good data here despite that.
Abstract
Background
Alopecia areata (AA) is characterized by an autoimmune inflammatory response to hair follicles. Several studies have suggested that infection and vaccination can trigger an autoimmune process around hair follicles. Moreover, reports of AA and various other autoimmune diseases have increased since the coronavirus disease 2019 (COVID-19) pandemic became established.
Objective
We assessed the clinical characteristics and treatment response in patients who developed AA following COVID-19 infection or vaccination.
Methods
This retrospective study involved patients who had developed COVID-19 or received a COVID-19 vaccination within 3 months before the onset or aggravation of AA from January 2020 to December 2022.
Results
Fifty patients met the inclusion criteria. Eighteen patients had a history of COVID-19 infection, and 32 had a history of COVID-19 vaccination. The mean onset of AA after COVID-19 infection and vaccination was 5.22±3.35 and 4.13±2.73 weeks, respectively. The most common COVID-19-associated symptoms before AA were fever (88.9%) in the infection group and myalgia (50.0%) in the vaccination group. In the vaccination group, AA most commonly occurred after receiving the Pfizer-BioNTech vaccine (BNT162b2, 46.9%) or Moderna vaccine (mRNA-1273, 34.4%). The vaccination group showed more rapid improvement than the infection group; however, both showed significant improvement after 6 months of treatment of AA.
Conclusion
We examined the clinical characteristics and treatment responses of patients who developed AA after COVID-19 infection or vaccination. Further research is needed to evaluate the detailed pathogenesis and association between COVID-19 and AA.
Keywords
Alopecia areata; Autoimmune diseases; COVID-19; Infection; Vaccination
Saving despite my absolute hatred for grouping together vaccine and infection: They don't even correct for the possibility of those people getting covid before or after vaccination, it's just "oh they got alopecia after a vaccination. That's a data point." They're wrong. It's not good science. It's conflation at best and corruption at worst. Some good data here despite that.
Abstract
Background
Alopecia areata (AA) is characterized by an autoimmune inflammatory response to hair follicles. Several studies have suggested that infection and vaccination can trigger an autoimmune process around hair follicles. Moreover, reports of AA and various other autoimmune diseases have increased since the coronavirus disease 2019 (COVID-19) pandemic became established.
Objective
We assessed the clinical characteristics and treatment response in patients who developed AA following COVID-19 infection or vaccination.
Methods
This retrospective study involved patients who had developed COVID-19 or received a COVID-19 vaccination within 3 months before the onset or aggravation of AA from January 2020 to December 2022.
Results
Fifty patients met the inclusion criteria. Eighteen patients had a history of COVID-19 infection, and 32 had a history of COVID-19 vaccination. The mean onset of AA after COVID-19 infection and vaccination was 5.22±3.35 and 4.13±2.73 weeks, respectively. The most common COVID-19-associated symptoms before AA were fever (88.9%) in the infection group and myalgia (50.0%) in the vaccination group. In the vaccination group, AA most commonly occurred after receiving the Pfizer-BioNTech vaccine (BNT162b2, 46.9%) or Moderna vaccine (mRNA-1273, 34.4%). The vaccination group showed more rapid improvement than the infection group; however, both showed significant improvement after 6 months of treatment of AA.
Conclusion
We examined the clinical characteristics and treatment responses of patients who developed AA after COVID-19 infection or vaccination. Further research is needed to evaluate the detailed pathogenesis and association between COVID-19 and AA.
Keywords
Alopecia areata; Autoimmune diseases; COVID-19; Infection; Vaccination