Post by Nadica (She/Her) on Nov 5, 2024 6:08:04 GMT
The clots removed from ischaemic stroke patients by mechanical thrombectomy are amyloid in nature - Preprint posted Nov 4, 2024
Abstract
Ischemic stroke due to large vessel occlusion results from the blockage of a major cerebral artery
by a clot; however, the origins and molecular composition of these clots remain poorly understood.
Mechanical thrombectomy has become a standard treatment to remove obstructive clots, providing
a unique opportunity to analyze their properties. We previously demonstrated that blood can clot into
an amyloid-like form, generating fibrinaloid microclots (2–200 μm) that are highly resistant to
fibrinolysis. In this study, archived clots from eight ischemic stroke patients with large vessel
occlusion were examined, using samples stored in the Walton Centre Clot Bank in Liverpool, UK. All
clots exhibited strong, heterogeneous amyloid staining, revealing a pervasive amyloid component.
These findings represent a previously unreported characteristic of stroke clots, highlighting the
potential for amyloid-targeted therapies to overcome their fibrinolytic resistance and providing a
foundational new insight into ischaemic stroke pathophysiology and treatment.
Abstract
Ischemic stroke due to large vessel occlusion results from the blockage of a major cerebral artery
by a clot; however, the origins and molecular composition of these clots remain poorly understood.
Mechanical thrombectomy has become a standard treatment to remove obstructive clots, providing
a unique opportunity to analyze their properties. We previously demonstrated that blood can clot into
an amyloid-like form, generating fibrinaloid microclots (2–200 μm) that are highly resistant to
fibrinolysis. In this study, archived clots from eight ischemic stroke patients with large vessel
occlusion were examined, using samples stored in the Walton Centre Clot Bank in Liverpool, UK. All
clots exhibited strong, heterogeneous amyloid staining, revealing a pervasive amyloid component.
These findings represent a previously unreported characteristic of stroke clots, highlighting the
potential for amyloid-targeted therapies to overcome their fibrinolytic resistance and providing a
foundational new insight into ischaemic stroke pathophysiology and treatment.