Post by Nadica (She/Her) on Oct 18, 2024 3:25:19 GMT
Effect of previous exposure to COVID-19, occurrence of spikes, and type of vaccine on the humoral immune response of institutionalized older adults - Published Oct 11, 2024
Efecto de la exposición previa a COVID-19, ocurrencia de brotes y tipo de vacuna en la respuesta inmune humoral de adultos mayores institucionalizados
Efeito da exposição prévia à COVID-19, ocorrência de picos e tipo de vacina na resposta imune humoral de adultos idosos institucionalizados
www.scielo.br/j/csp/a/wRC4PYYLTFwJmgbSCfpyXjF/abstract/?lang=en (Abalável in the three languages above)
Abstract:
This study evaluated the explanatory factors of humoral immune response in older adults admitted to long-term care institutions in Buenos Aires, Argentina, up to 180 days after vaccination. An open-label, prospective, multicenter cohort study was conducted with volunteers who received two doses of the Sputnik V, Sinopharm, or AZD1222 vaccines. Plasma samples were analyzed at 0 and 21 days after the first dose, 21 days after the second dose, and 120 and 180 days after the first dose. Marginal linear models and generalized additives mixed models were adjusted to determine the behavior of anti-spike IgG antibody concentration over time according to exposure group (naïve/no-naïve) and vaccine. Occurrence of an outbreak of COVID-19 in long-term care institutions and comorbidities were the covariates analyzed. A total of 773 participants were included, with a mean age of 83 years (IQR: 76-89). Results showed that antibody levels in the naïve: Sinopharm group were significantly lower to the other groups (p < 0.05). Antibody levels in the no-naïve: Sinopharm group were similar to those in the naïve group who received AZD1222 (p = 0.945) or Sputnik V (p = 1). Participants exposed to outbreaks in long-term care institutions had significantly higher antibody levels, regardless of exposure group and vaccine (p < 0.001). In conclusion, previous exposure to COVID-19, type of vaccine, and admittance into a long-term care institution with a history of outbreaks are factors to be considered in future epidemic events with transmission dynamics and immunological mechanisms similar to COVID-19, in populations similar to the one analyzed.
Keywords:
Coronavirus Infections; Vaccine Immunogenicity; Health of Institutionalized Elderly; Pandemics
Efecto de la exposición previa a COVID-19, ocurrencia de brotes y tipo de vacuna en la respuesta inmune humoral de adultos mayores institucionalizados
Efeito da exposição prévia à COVID-19, ocorrência de picos e tipo de vacina na resposta imune humoral de adultos idosos institucionalizados
www.scielo.br/j/csp/a/wRC4PYYLTFwJmgbSCfpyXjF/abstract/?lang=en (Abalável in the three languages above)
Abstract:
This study evaluated the explanatory factors of humoral immune response in older adults admitted to long-term care institutions in Buenos Aires, Argentina, up to 180 days after vaccination. An open-label, prospective, multicenter cohort study was conducted with volunteers who received two doses of the Sputnik V, Sinopharm, or AZD1222 vaccines. Plasma samples were analyzed at 0 and 21 days after the first dose, 21 days after the second dose, and 120 and 180 days after the first dose. Marginal linear models and generalized additives mixed models were adjusted to determine the behavior of anti-spike IgG antibody concentration over time according to exposure group (naïve/no-naïve) and vaccine. Occurrence of an outbreak of COVID-19 in long-term care institutions and comorbidities were the covariates analyzed. A total of 773 participants were included, with a mean age of 83 years (IQR: 76-89). Results showed that antibody levels in the naïve: Sinopharm group were significantly lower to the other groups (p < 0.05). Antibody levels in the no-naïve: Sinopharm group were similar to those in the naïve group who received AZD1222 (p = 0.945) or Sputnik V (p = 1). Participants exposed to outbreaks in long-term care institutions had significantly higher antibody levels, regardless of exposure group and vaccine (p < 0.001). In conclusion, previous exposure to COVID-19, type of vaccine, and admittance into a long-term care institution with a history of outbreaks are factors to be considered in future epidemic events with transmission dynamics and immunological mechanisms similar to COVID-19, in populations similar to the one analyzed.
Keywords:
Coronavirus Infections; Vaccine Immunogenicity; Health of Institutionalized Elderly; Pandemics