Post by Nadica (She/Her) on Oct 6, 2024 2:25:21 GMT
Association between SARS-CoV-2 and Stroke: Perspectives from a metaumbrella-review. - Preprint Posted Oct 3, 2024
Abstract
In the face of the global COVID-19 pandemic, the need arose to investigate potential complications associated with SARS-CoV-2, including the risk of Stroke. Objective: This study aimed to verify the association between SARS-CoV-2 and the risk of Stroke, based on systematic reviews and meta-analyses, in order to assess the inclusion of the virus as a new risk factor for cerebrovascular diseases. Methods: A metaumbrella was conducted, which included 34 systematic reviews, of which 4 were selected for the final analysis based on methodological quality and consistency. The analysis aggregated the results of 70 primary studies, considering different stroke subtypes and outcomes associated with COVID-19. Study heterogeneity was assessed using the I2 index, and significance bias was verified using Egger's test. Results: The analysis showed that the severity of COVID-19 is significantly associated with an increased risk of stroke (eOR = 2.48; 95%CI: 1.55 - 3.95), particularly for ischemic stroke (eOR = 1.76; 95%CI: 1.11 - 2.80) and hemorrhagic stroke (eOR = 3.86; 95%CI: 1.79 - 8.33). Additionally, patients with cerebrovascular comorbidities had higher mortality (eOR = 2.48; 95%CI: 2.48 - 19.63), as did those who had previously suffered a stroke (eOR = 6.08; 95%CI: 3.73 - 9.91). Conclusion: The association between SARS-CoV-2 and stroke was consistent and significant, suggesting that COVID-19 should be considered a new risk factor for cerebrovascular diseases. However, the high heterogeneity among the studies analyzed reinforces the need for further research to consolidate this relationship.
Abstract
In the face of the global COVID-19 pandemic, the need arose to investigate potential complications associated with SARS-CoV-2, including the risk of Stroke. Objective: This study aimed to verify the association between SARS-CoV-2 and the risk of Stroke, based on systematic reviews and meta-analyses, in order to assess the inclusion of the virus as a new risk factor for cerebrovascular diseases. Methods: A metaumbrella was conducted, which included 34 systematic reviews, of which 4 were selected for the final analysis based on methodological quality and consistency. The analysis aggregated the results of 70 primary studies, considering different stroke subtypes and outcomes associated with COVID-19. Study heterogeneity was assessed using the I2 index, and significance bias was verified using Egger's test. Results: The analysis showed that the severity of COVID-19 is significantly associated with an increased risk of stroke (eOR = 2.48; 95%CI: 1.55 - 3.95), particularly for ischemic stroke (eOR = 1.76; 95%CI: 1.11 - 2.80) and hemorrhagic stroke (eOR = 3.86; 95%CI: 1.79 - 8.33). Additionally, patients with cerebrovascular comorbidities had higher mortality (eOR = 2.48; 95%CI: 2.48 - 19.63), as did those who had previously suffered a stroke (eOR = 6.08; 95%CI: 3.73 - 9.91). Conclusion: The association between SARS-CoV-2 and stroke was consistent and significant, suggesting that COVID-19 should be considered a new risk factor for cerebrovascular diseases. However, the high heterogeneity among the studies analyzed reinforces the need for further research to consolidate this relationship.