Post by Nadica (She/Her) on Aug 2, 2024 2:52:49 GMT
Impact of Diabetes on Persistent Radiological Abnormalities and Pulmonary Diffusion Dysfunction in COVID-19 Survivors: A 3-Year Prospective Cohort Study - Published July 27, 2024
Study shows increased long-term risk of respiratory and heart issues following covid infection in diabetic people.
Rationale and Objectives
Little is known about the long-term impact of diabetes on lung impairment in COVID-19 survivors over a three-year period. This study evaluated the long-term impact of diabetes on persistent radiological pulmonary abnormalities and lung function impairment in COVID-19 survivors over three years.
Materials and Methods
In this prospective, multicenter, cohort study, pulmonary sequelae were compared between COVID-19 survivors with and without diabetes. Serial chest CT scans, symptom questionnaires and pulmonary function tests were obtained 6 months, 12 months, 2 years and 3 years post-discharge. The independent predictors for lung dysfunction at the 3-year follow-up were analyzed.
Results
A total of 278 COVID-19 survivors (63 [IQR 57–69] year-old, female: 103 [37.0%]) were included. At the 3-year follow-up, individuals in the diabetes group had higher incidences of respiratory symptoms, radiological pulmonary abnormalities and pulmonary diffusion dysfunction than those in the control group. Diabetes (OR: 2.18, 95% CI: 1.04–4.59, p = 0.034), allergy (OR: 2.26, 95% CI: 1.09–4.74, p = 0.029), female (OR: 2.70, 95% CI: 1.37–5.29, p = 0.004), severe COVID-19 (OR: 4.10, 95% CI: 1.54–10.93, p = 0.005), and fibrotic-like CT changes (OR: 5.64, 95% CI: 2.28–13.98, p < 0.001) were independent predictors of pulmonary diffusion dysfunction in COVID-19 survivors.
Conclusion
These results highlight the long-term deleterious effect of diabetes status on radiological pulmonary abnormalities and pulmonary dysfunction in COVID-19 survivors. This study provides important evidence support for long-term monitoring of lung abnormalities in COVID-19 recovery survivors with diabetes.
Study shows increased long-term risk of respiratory and heart issues following covid infection in diabetic people.
Rationale and Objectives
Little is known about the long-term impact of diabetes on lung impairment in COVID-19 survivors over a three-year period. This study evaluated the long-term impact of diabetes on persistent radiological pulmonary abnormalities and lung function impairment in COVID-19 survivors over three years.
Materials and Methods
In this prospective, multicenter, cohort study, pulmonary sequelae were compared between COVID-19 survivors with and without diabetes. Serial chest CT scans, symptom questionnaires and pulmonary function tests were obtained 6 months, 12 months, 2 years and 3 years post-discharge. The independent predictors for lung dysfunction at the 3-year follow-up were analyzed.
Results
A total of 278 COVID-19 survivors (63 [IQR 57–69] year-old, female: 103 [37.0%]) were included. At the 3-year follow-up, individuals in the diabetes group had higher incidences of respiratory symptoms, radiological pulmonary abnormalities and pulmonary diffusion dysfunction than those in the control group. Diabetes (OR: 2.18, 95% CI: 1.04–4.59, p = 0.034), allergy (OR: 2.26, 95% CI: 1.09–4.74, p = 0.029), female (OR: 2.70, 95% CI: 1.37–5.29, p = 0.004), severe COVID-19 (OR: 4.10, 95% CI: 1.54–10.93, p = 0.005), and fibrotic-like CT changes (OR: 5.64, 95% CI: 2.28–13.98, p < 0.001) were independent predictors of pulmonary diffusion dysfunction in COVID-19 survivors.
Conclusion
These results highlight the long-term deleterious effect of diabetes status on radiological pulmonary abnormalities and pulmonary dysfunction in COVID-19 survivors. This study provides important evidence support for long-term monitoring of lung abnormalities in COVID-19 recovery survivors with diabetes.