Post by Nadica (She/Her) on Jul 28, 2024 2:13:53 GMT
Trajectories of the evolution of post-COVID-19 condition, up to two years after symptoms onset - Published May 27, 2023
Highlights
•A total of 91% of patients with post-COVID-19 condition improved slowly over a 2-year course.
•Of them, 5% improved rapidly and 4% had a persistent condition.
•Trajectories were associated with patients’ characteristics and symptoms.
Abstract
Objectives
We aimed to identify trajectories of the evolution of post-COVID-19 condition, up to 2 years after symptom onset.
Methods
The ComPaRe long COVID e-cohort is a prospective cohort of patients with symptoms lasting at least 2 months after SARS-CoV2 infection. We used trajectory modeling to identify different trajectories in the evolution of post-COVID-19 condition, based on symptoms collected every 60 days using the long COVID Symptom Tool.
Results
A total of 2197 patients were enrolled in the cohort between December 2020 and July 2022 when the Omicron variant was not dominant. Three trajectories of the evolution of post-COVID-19 condition were identified: “high persistent symptoms” (4%), “rapidly decreasing symptoms” (5%), and “slowly decreasing symptoms” (91%). Participants with highly persistent symptoms were older and more likely to report a history of systemic diseases. They often reported tachycardia, bradycardia, palpitations, and arrhythmia. Participants with rapidly decreasing symptoms were younger and more likely to report a confirmed infection. They often reported diarrhea and back pain. Participants with slowly decreasing symptoms were more likely to have a history of functional diseases.
Conclusion
Most patients with post-COVID-19 condition improve slowly over time, while 5% have rapid improvement in the 2 years after symptom onset and 4% have a persistent condition.
Highlights
•A total of 91% of patients with post-COVID-19 condition improved slowly over a 2-year course.
•Of them, 5% improved rapidly and 4% had a persistent condition.
•Trajectories were associated with patients’ characteristics and symptoms.
Abstract
Objectives
We aimed to identify trajectories of the evolution of post-COVID-19 condition, up to 2 years after symptom onset.
Methods
The ComPaRe long COVID e-cohort is a prospective cohort of patients with symptoms lasting at least 2 months after SARS-CoV2 infection. We used trajectory modeling to identify different trajectories in the evolution of post-COVID-19 condition, based on symptoms collected every 60 days using the long COVID Symptom Tool.
Results
A total of 2197 patients were enrolled in the cohort between December 2020 and July 2022 when the Omicron variant was not dominant. Three trajectories of the evolution of post-COVID-19 condition were identified: “high persistent symptoms” (4%), “rapidly decreasing symptoms” (5%), and “slowly decreasing symptoms” (91%). Participants with highly persistent symptoms were older and more likely to report a history of systemic diseases. They often reported tachycardia, bradycardia, palpitations, and arrhythmia. Participants with rapidly decreasing symptoms were younger and more likely to report a confirmed infection. They often reported diarrhea and back pain. Participants with slowly decreasing symptoms were more likely to have a history of functional diseases.
Conclusion
Most patients with post-COVID-19 condition improve slowly over time, while 5% have rapid improvement in the 2 years after symptom onset and 4% have a persistent condition.