Post by Nadica (She/Her) on Jul 19, 2024 22:56:02 GMT
The risks of POTS after COVID-19 vaccination and SARS-CoV-2 infection: more studies are needed - Published Dec 12, 2022
Stating as always, any proof of "vaccine injury" is hazy at best given that no one ever corrects for the possibility of asymptomatic infections being missed and subsequent long covid.
Postural orthostatic tachycardia syndrome (POTS) can follow COVID-19 as part of the post-acute sequelae of SARS-CoV-2 infection, but it can also develop after COVID-19 vaccination, although at a lower frequency.
Vaccines represent one of the most groundbreaking scientific advances that substantially reduced the mortality and morbidity associated with various infectious pathogens. Since the introduction of COVID-19 vaccines in the USA in December 2020, vaccination against SARS-CoV-2 has remained the most effective and influential global public health strategy to mitigate the pandemic. However, reports of post-vaccination adverse events involving various cardiovascular and neurological manifestations, including POTS, have been mounting in the Vaccine Adverse Event Reporting System1.
POTS, a common disorder of the autonomic nervous system, is characterized by an increase in heart rate of at least 30 beats per minute within 10 minutes of standing and symptoms of orthostatic intolerance, such as pre-syncope, palpitations, light-headedness, generalized weakness, headache and nausea, with symptom duration exceeding three months2. In the USA, the pre-pandemic prevalence of POTS has been estimated to be in the range of 500,000–3,000,000 people, affecting predominantly women of reproductive age and roughly 1 in 100 teenagers3. However, current prevalence is likely significantly higher owing to post-COVID-19 POTS, which can develop as part of the post-acute sequelae of SARS-CoV-2 infection (PASC)4,5.
New-onset POTS can also follow vaccination (Fig. 1) and was reported in the literature after immunization with Gardasil, a human papillomavirus (HPV) vaccine, in 2010 and, more recently, after the administration of COVID-19 vaccines6,7,8. However, a causative relationship between HPV vaccines and increased incidence of POTS has not been thoroughly investigated. This is despite several case series reported from different countries and two studies that demonstrated an increased signal for POTS and its associated symptom clusters following HPV vaccination, based on data from the World Health Organization’s pharmacovigilance database and a meta-analysis of clinical study reports from 24 clinical trials9,10,11.
Stating as always, any proof of "vaccine injury" is hazy at best given that no one ever corrects for the possibility of asymptomatic infections being missed and subsequent long covid.
Postural orthostatic tachycardia syndrome (POTS) can follow COVID-19 as part of the post-acute sequelae of SARS-CoV-2 infection, but it can also develop after COVID-19 vaccination, although at a lower frequency.
Vaccines represent one of the most groundbreaking scientific advances that substantially reduced the mortality and morbidity associated with various infectious pathogens. Since the introduction of COVID-19 vaccines in the USA in December 2020, vaccination against SARS-CoV-2 has remained the most effective and influential global public health strategy to mitigate the pandemic. However, reports of post-vaccination adverse events involving various cardiovascular and neurological manifestations, including POTS, have been mounting in the Vaccine Adverse Event Reporting System1.
POTS, a common disorder of the autonomic nervous system, is characterized by an increase in heart rate of at least 30 beats per minute within 10 minutes of standing and symptoms of orthostatic intolerance, such as pre-syncope, palpitations, light-headedness, generalized weakness, headache and nausea, with symptom duration exceeding three months2. In the USA, the pre-pandemic prevalence of POTS has been estimated to be in the range of 500,000–3,000,000 people, affecting predominantly women of reproductive age and roughly 1 in 100 teenagers3. However, current prevalence is likely significantly higher owing to post-COVID-19 POTS, which can develop as part of the post-acute sequelae of SARS-CoV-2 infection (PASC)4,5.
New-onset POTS can also follow vaccination (Fig. 1) and was reported in the literature after immunization with Gardasil, a human papillomavirus (HPV) vaccine, in 2010 and, more recently, after the administration of COVID-19 vaccines6,7,8. However, a causative relationship between HPV vaccines and increased incidence of POTS has not been thoroughly investigated. This is despite several case series reported from different countries and two studies that demonstrated an increased signal for POTS and its associated symptom clusters following HPV vaccination, based on data from the World Health Organization’s pharmacovigilance database and a meta-analysis of clinical study reports from 24 clinical trials9,10,11.